Report of the Association Between Multisystem Inflammatory Syndrome and Severe Myocarditis

Introduction: The people worldwide have been affected by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection since its appearance in December, 2019. Kawasaki disease-like hyperinflammatory shock associated with SARS-CoV-2 infection in previously healthy children has been reported in the literature, which is now referred to as a multisystem inflammatory syndrome in children (MIS-C). Some aspects of MIS-C are similar to those of Kawasaki disease, toxic shock syndrome, secondary hemophagocytic syndrome, and macrophage activation syndrome. Case Presentation: This study reported an 11-year-old boy with MIS-C presented with periorbital and peripheral edema, abdominal pain, elevated liver enzymes, severe right pleural effusion, moderate ascites, and severe failure of right and left ventricles. Conclusion(s): Due to the increasing number of reported cases of critically ill patients afflicted with MIS-C and its life-threatening complications, it was recommended that further studies should be carried out in order to provide screening tests for myocardial dysfunction. Adopting a multidisciplinary approach was found inevitable.Copyright © 2023, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

A Case Series of COVID-19 Respiratory Infection in Hospitalized Children: Clinical and Computed Tomography Challenges

Our objective was to evaluate clinical and computed tomographic features in hospitalized children with COVID-19 infection who were admitted to the pediatric center of excellence, children's medical center. In this case-series, we report twelve patients with clinical symptoms of acute respiratory infections at the beginning or after admission who have PCR-proved (throat swab samples) COVID-19 infection and underwent computed tomography imaging. Six patients had an underlying disease and atypical findings with no clinical suspicion at the beginning. Tachypnea (75%) represented the most common physical finding. Computed tomography was abnormal in 83.3% of patients. Subpleural consolidation, peribronchial thickening, round consolidation, and Halo sign was depicted. The empirical regimen in our hospital included hydroxychloroquine and oseltamivir. Some of the patients managed easily, but others had prolonged hospital stay, especially patients with significant underlying conditions.